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Quality Assessment of Selected Indian Medicinal Plants, Volume 1

 
Amit Agarwal (Author) Balasubramanian Murali (Author)
Synopsis
This book is the outcome of a project; part funded by NMPB, on development of quality assessment parameters for selected Indian medicinal plants. The project involved standardization of 16 different medicinal plants, ten out of which have been covered in the first volume of this book series.

The quality assessment of medicinal plants becomes complex and challenging due to multiple end uses of each herb, lack of clear knowledge about the bio-active constituents, inherent phytochemical variations and non-availability of relevant reference standards. It is needless to say that the quality of the finished herbal products is directly dependent on the quality of the herbal raw material. In India, the entire herbal industry can be broadly classified into two groups, viz. traditional herbal industry (Ayurveda, Siddha and Unani medicine manufacturers) and modern herbal industry (manufacturers of standardized extracts, phytochemicals, oleoresins, cosmetics, nutraceuticals, etc.).

The quality assessment paradigms of both these types of herbal industries are very different. As a generalization, the traditional medicine manufacturers do not believe in the concept of active principles / marker compounds for quality assessment, as they believe that the entire herb or its preparation is bio-active. On the other hand the modern herbal product manufacturers prefer to assess quality based on the content of specific secondary metabolites which are believed to be important for the overall biological effect of a given herb or its preparation. This book aims to serve mainly the later type of industry, as it utilizes a series of objectively verifiable quality assessment parameters.

In the international market also, natural products are often valued based on the content of specific active principles / secondary metabolites / marker compounds. In the recent years, several definitions have emerged for active compounds, bio-markers, markers, analytical markers etc. For the sake of simplicity, in this book, we have referred to these compounds as desirable compounds or commercially pursued compounds. The higher the content of desirable compounds, the higher is the value of an herb or its preparation in the international market.

The task is challenging as till date there is no clear and general agreement as to which constituents should be considered as desirable. There is a paucity of basic research which links the secondary metabolites with specific biological activities. For almost two decades (1970's to 1990's) there was a trend of isolation and characterization of secondary metabolites from medicinal plants with little or no regard to their bio-activity. During this period, a large number of phyto-constituents were reported without any knowledge about their utility. It is only when the international, peer reviewed, scientific journals started refusing to publish any research, where the isolated new constituents were not linked to any bio-activity, the trend started to change towards multi-disciplinary research involving both Phytochemistry and Pharmacology. Even today, for many Indian medicinal plants, the desirable compounds are not known. As a result, there is an uncertainty as to which compounds should be analyzed for a fair assessment of quality of such medicinal plants. For the purpose of this book, we have used the criterion that a phyto-compound should have preferably two in-vivo studies or a clinical study demonstrating efficacy in a particular condition for it to be considered as a desirable compound. Due to the ADME related limitations of in-vitro phannacological methods, the compounds found to be active only in the in-vitro assays were not considered for this assessment.
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About the authors

Amit Agarwal

Dr. Amit Agarwal is the Director of Research & Development at Natural Remedies. He obtained his Master's degree in Pharmacology from University of Strathclyde, UK and holds a Ph.D. in Pharmacology. He has over 20 years of experience in research and development of natural products. He has published 56 research papers, 82 abstracts, contributed to 6 books and has 5 patents granted till date, to his credit.

He is the editor of the "Journal of Natural Remedies". He serves as areviewer, member of the editorial board of several national and international journals. He is a member of the Herbal Products and Crude Drugs Committee of the Indian Pharmacopoeia Commission, and a member of Project Screening Committee of National Medicinal Plants Board. He is a recognized Ph.D. guide of Manipal University.

Balasubramanian Murali

Mr. Balasubramanian Murali is the Senior Manager, Dept. of Analytical Chemistry, Natural Remedies. He holds a Master's degree in Chemistry and leads a team of 36 analytical chemists. He has over 23 years of experience in the field of analytical chemistry. He has developed and validated several analytical methods. He has published over 15 research papers and contributed chapters in some books.

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Bibliographic information

Title Quality Assessment of Selected Indian Medicinal Plants, Volume 1
Format Hardcover
Date published: 31.12.2010
Edition 1st ed.
Language: English
isbn 9788191009309
length 293p., 24cm.