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Concepts in Chronopharmacology

 
N Udupa (Editor) P D Gupta (Editor)
Synopsis The metabolic fate of a drug is not constant in humans; it is a function of time chronopharmacology, therefore has crept in almost all branches of pharmaceutical sciences, because of its importance in the drug design, development, bioavailability, efficacy, prescription and administration. By timing a drug, its toxicity can be reduced. Chronopharmacology deals with the time dependent peaks and troughs in the action of drugs and other pharmaceuticals in the body. In the present scenario, it is possible to explain all the functions of the body as a function of time. In the same way as sleep-wake, feed-hunger and joy-depression are regulated by the living clocks, the maximum efficacy and minimum toxicity of a drug can be achieved if it is administered at the appropriate time; i.e., right drug in the right form, at the right dose, at the right time. So the given drug can act synergistically with biological clock. For example, sleeping pill should be taken in the nighttime to produce good results.

Individual rhythmic oscillations will change the mode of check up and treatment timings, depending on the answers given by an individual regarding bed time routine, meal timings, phase of menstrual cycle, exposure to Sunlight, time spent on watching TV and time spent on working on the computer etc. various surgeries can be planned, type of anesthesia and organ transplant can be decided, Change in the core temperature will indicate the danger of infection rather than induction of fever and depending on sensitivity of breast tissue of hormones, breast biopsies and blood samplings can be planned.

The scope of the book is very wide; the Editors hope that every Pharmacologist will make best use of the present book.
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About the authors

N Udupa

Dr. N. Udupa graduated from Banaras Hindu University, Varanasi, India in 1987. After serving in Pharma Industry, he came back to academics and now he is occupying the highest position as Principal at Manipal College of Pharmaceutical Sciences Manipal University for last 22 years and received Principal of the Year (2001) Award from APTI. Dr. Udupa has received best paper awards in Conferences and he was selected for Professor Premchand Dandiya Endowment Trust, Jaipur for first Annual Research Award in January 1997. He has fancy for development new branches in pharmaceutical sciences and he was recognized as Pharmaceutical Scientist of the year 2008 Award from Indian Association of Pharmaceutical Scientists and Technologist.

P D Gupta

Dr. P.D. Gupta was associated with many prestigious institutions in India and abroad as a teacher and researcher. He has served at the Department of surgery. University of Pennsylvania, Philadelphia, USA. The All India Institute of Medical Sciences, New Delhi and CCMB, Hyderabad. Currently he is Research Advisor /Visiting Professor of Manipal University, Manipal and BITS, Pilani. He has received Best Invention and Life Time Achievement Awards. He has worked on born blind rat model and published many papers on Chronobiology and Effects of light and dark periods on rhythms in Brain Research and other prestigious journals.

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Bibliographic information

Title Concepts in Chronopharmacology
Format Hardcover
Date published: 31.12.2009
Edition 1st ed.
Publisher Shyam Prakashan
Language: English
isbn 9789380018092
length xii+183p., Illustrations; Figures; Tables; Index; 25cm.