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Synopsis This book assembles most of the methods for screening substances for pharmacological activity and includes discussions of the organization of screening programs. While screening is widely practiced in pharmacology laboratories, a definition of its meaning is perhaps worthy of attention. The term screening indicates the use of a combination of tests for the purpose of making a decision. The results of the tests provide information on the presence of certain pharmacological properties. The present work is obviously directed to those whose occupation it is to search for new pharmaceuticals. A variety of investigators in the fields of pharmacology, physiology, toxicology, and therapeutics may also find useful methods for their research. Chemists in the pharmaceutical industry who read this book will be aided in their understanding of the basis for testing the compounds that they synthesize and in their understanding of the programs for testing that the pharmcologist has devised.