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This book is a comprehensive introduction to quantitative approaches to complex adaptive systems. Practically all areas of life on this planet are constantly confronted with complex systems, be it ecosystems, societies, traffic, financial markets, opinion formation and spreading, or the internet and social media. Complex systems are systems composed of many elements that interact strongly with each other, which makes them extremely rich dynamical systems showing a huge range of phenomena. Properties of complex systems that are of particular importance are their efficiency, robustness, resilience, and proneness to collapse. The quantitative tools and concepts needed to understand the co-evolutionary nature of networked systems and their properties are challenging. The book gives a self-contained introduction to these concepts, so that the reader will be equipped with a toolset that allows them to engage in the science of complex systems. Topics covered include random processes of path-dependent processes, co-evolutionary dynamics, dynamics of networks, the theory of scaling, and approaches from statistical mechanics and information theory. The book extends beyond the early classical literature in the field of complex systems and summarizes the methodological progress made over the past 20 years in a clear, structured, and comprehensive way.