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Key Features: • Concise guide to the practical management of infections following orthopedic procedures. • Designed to help answer clinicians' questions regarding the prevention and treatment of periprosthetic joint infection. • Organized for rapid review, featuring up-to-date citations and current Rothman Institute Protocols, Practices, and Controversies in every chapter. • Discusses current evidences and pitfalls. • Important points provided in boxes for quick eference. • Supplemented with lots of tables and clinical images for better understanding. • References for further reading in every chapter. 

Contents: I. Basics of Infection/Jonathan R Danoff: 1. Definition of Periprosthetic Joint Infections/Jonathan R Danoff. 2. Incidence and Burden of Periprosthetic Joint Infection/Jonathan R Danoff. 3. Economic Burden of Periprosthetic Joint Infection/Jonathan R Danoff. 4. Common Antibiotics and Mechanism of Action/Nana O Sarpong. 5. Biofilm/Alexander L Neuwirth. 6. Multidisciplinary Approach to Management of Periprosthetic Joint Infections/Matthew J Grosso. 7. Future Trends and Challenges/Joseph A Karam and Peter F Sharkey. II. Preoperative Medical Optimization/Jonathan R Danoff, Christopher P Bechtel: 8. Predisposing Factors for Periprosthetic Joint Infection/Jonathan R Danoff. 9. Perioperative Management of Diabetes Mellitus and Hyperglycemia/Jonathan R Danof. 10. Malnutrition and Obesity/Matthew J Grosso. 11. Cigarette and Tobacco Risks/Rahul Goel. 12. Prior Intra-articular Joint Injection and Risk of Infection/Nana O Sarpong. 13. Perioperative Management of Home Medications and Supplements/Nana O Sarpong. 14. Inflammatory Arthropathy/Matthew J Grosso. 15. Total Joint Arthroplasty in Patients with Prior Septic Arthritis/Joseph A Karam. 16. Perioperative Management of Concomitant Infections/Alexander L Neuwirth. 17. Conversion Arthroplasty with Hardware in Situ/William V Arnold. 18. Liver and Kidney Disease/Christopher P Bechtel and Antonia F Chen.19. Anemia/Christopher P Bechtel and Javad Parvizi. 20. Peripheral Vascular Disease/John Kozy and Christopher P Bechtel. 21. Alcohol and Drug Use/Christopher P Bechtel. 22. Depression and Other Psychiatric Illnesses/Christopher P Bechtel. 23. Anticoagulation and Prosthetic Joint Infection/Blake A Eyberg. 24. Infection Prevention Guidelines/Noam Shohat and Christopher P Bechtel. III. Intraoperative and Postoperative Optimization/Asim M Makhdom: 25. Preoperative Skin Preparation: Decolonization and Antisepsis/Vinay Aggarwal and Anthony Tokarski. 26. Operating Room Environment/Matthew Silijander. 27. Incise Drapes/Alvin Ong and Asim M Makhdom. 28. Antibiotic Prophylaxis/Nora Almadani and Asim M Makhdom. 29. Workup of Patients with Suspected Urinary Tract Infection/Nora Almadani and Asim M Makhdom. 30. Irrigation Solutions in Total Joint Arthroplasty/Matthew Silijander. 31. Cement and Antibiotics/Claudio Diaz- Ledezma. 32. Blood Conservation/Christopher P Bechtel and Daniel Baquet. 33. Wound Closure and Drain Use/Asim M Makhdom. 34. Postarthroplasty Antibiotic Prophylaxis/Fabio Orozco and Asim M Makhdom. IV. Diagnosis of Infection/Christopher P Bechtel: 35. Available Diagnostic Laboratory Tests and Molecular Biomarkers/Majd Tarabichi. 36. Joint Aspiration/Jonathan R Danoff. 37. Imaging for Diagnosis of Periprosthetic Joint Infection/Nachum B Stollman and Ronald A Pitt. 38. Culture Principles/Christopher P Bechtel and Gregory K Deirmengian. 39. Culture-negative Periprosthetic Joint Infections/Christopher P Bechtel and Carlos A Higuera. 40. Diagnosis of Periprosthetic Joint Infection in Inflammatory Conditions/James F Fraser. 41. Diagnosis of Periprosthetic Joint Infection in Adverse Metal Reaction/James F Fraser. 42. Diagnosing Periprosthetic Joint Infection: The Rothman Institute Algorithm/James F Fraser. Section 5: Treatment of Periprosthetic Joint Infection/James F Fraser and R Andrew Henderson. 43. Management of Wound Drainage/James J Purtill. 44. Management of Fungal Periprosthetic Joint Infections/Khalid Azzam. 45. Management of Mycobacterial Infection/Hooman Bakhshi. 46. Management of Periprosthetic Joint Infection Caused by Enterococcus/Michael M Kheir. 47. Periprosthetic Joint Infection Caused by Rare Organisms/Pierce Johnson. 48. Irrigation and Debridement for Periprosthetic Joint Infection/James F Fraser. 49. One-stage Exchange Arthroplasty for Periprosthetic Joint Infection/R Andrew Henderson and Erik N Hansen. 50. Resection Arthroplasty/Daniel S Mangiapani and Pouya Alijanipour. 51. Removal of Well-fixed Hip and Knee Arthroplasty Components in the Setting of Periprosthetic Joint Infection/R Andrew Henderson and Gregory K Deirmengian. 52. Two-stage Exchange Arthroplasty: Antibiotic Spacers/Vinay Aggarwal and Gregory K Deirmengian. 53. Reimplantation Following Two-stage Exchange Arthroplasty for Prosthetic Joint Infection/R Andrew Henderson and Camilo Restrepo. 54. Suppressive Antimicrobial Therapy and Prosthetic Joint Infection/Mitchell R Klement, Meaghan Cotter and Jai Hyung Park. 55. Prognostic Classification for Periprosthetic Joint Infection/Ronald Huang. 56. Periprosthetic Joint Infection and Mortality/R Andrew Henderson. 57. Current Limitations, Evolving Technologies and Future Directions in the Management of Periprosthetic Joint Infection/Asim M Makhdom. Index.