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In this edition, the system-based protocols are divided into 20 sub-sections. Each section has been written by esteemed faculty with substantial authority on that subject. All the aspects of basic and advanced life support as per recent Pediatric Advanced Life Support (PALS) guidelines are incorporated. In basic mechanical ventilation, protocols on trouble shooting, ventilation, weaning, extubation, prone positioning, recruitment maneuvers and tracheotomy are added. Shock has been revised and new American College of Critical Care Medicine (ACCM) guidelines for septic shock are included. Protocols on advanced therapies, and tropical infections are added with chapters on antibiotics and antifungals in PICU. Special chapter on fluids in different situations in PICU has been added. Chapters on DIC, transfusion of blood and blood products, transfusion reactions and oncological emergencies are added in Hematology section. Gastroenterology section is added with protocols on acute pancreatitis and surgical abdomen. Protocols on renal replacement therapy are also newly added. There is a new addition on common respiratory problems like severe pneumonia, bronchiolitis, acute croup, empyema, acute respiratory distress syndromes (ARDS) and air leak syndrome. In environmental injuries section, management issues about heat stroke, burns, electrical injury, poly trauma and drowning are included. New sections on quality care in PICU and medicolegal issues in PICU are specially incorporated to address the special needs of the present era.Key Features: • Great resource for residents, postgraduate fellows and also for PICU consultants to deliver evidence-based updated management in readily available format. • Edited by national experts and contributed by eminent pediatric intensivists and academicians from all over India and abroad. • Evidence-based and practical-oriented updated protocols have been used in easy to read format with flow charts and diagrams. • Incorporates Pediatric Advanced Life Support (PALS) guidelines. • Would be available in all emergency room and pediatric intensive care units as well as medical colleges. • It would be used to improve the outcome of critically ill children.